Along with his wife, Anne-Louise, the Deputy Mayor will walk 26 miles, following paths, tracks and the coastline of the Causeway Coast Way.
The event, organised by 26 Extreme, passes through stunning coastline scenery with exquisite views of wide bays, sandy beaches, dramatic cliffs and offshore rocks.
Cllr Colin McCusker said: "My wife has taken part in one of the other 26 Extreme challenges, the Mourne Way Marathon, and she has been asking me to take part in a similar event for a couple of years.
When I was made aware of the Homes from Home Appeal, I decided to help raise money for this charity as part of my year as Deputy Mayor, as well as taking up the challenge laid down by my wife. This is a very worthwhile local Appeal which will provide much needed accommodation for families in Northern Ireland."
When a child or young person in Northern Ireland is diagnosed with cancer, families can travel an average of up to 500 miles a week to access the treatment they need. They already face a huge emotional and financial strain with a cancer diagnosis without the added stress of travel.
CLIC Sargent aims to ease that burden by building free, self-catering accommodation close to the two main Belfast hospitals, for families when their child is getting treatment for cancer.
CLIC Sargent Fundraising Manager, Gemma McCallan said: "The Deputy Mayor and his wife, Anne-Louise, are certainly taking on a challenge for CLIC Sargent and we are very grateful for their support.
"Their fundraising efforts will go towards the Homes from Home Appeal which will be a fantastic resource for families in Northern Ireland. We wish them both the best of luck and look forward to hearing all about it when they return!
Find out more
To find out how you can help raise funds for children and young people with cancer, please contact Gemma McCallon on 02890 725 780 or email: email@example.com.
Visit the 26 Extreme official website for more information on how you can take part in the Causeway Coast Challenge Walk.