Matalan employee, Annie Laflin, encouraged colleagues to take part in the Wig Wendesday event when her grandson, Ashley was diagnosed with Wilm's Tumor earlier this year.
Staff at the Bury St Edmunds store also contributed to a month-long campaign in the store, with collection tins at every till point.
Lisa, Manager of the Bury St Edmunds store, said: “We had so much fun showing off some fabulous wigs while raising as much money as possible for CLIC Sargent.
"We are thrilled to have raised £655 to support children and young people with cancer.”
Ashley's mother said:
Our CLIC Sargent Support Worker Christine and the nurses from Ipswich Hospital have all been a true blessing.
“Their amazing care and support both financially - by providing small grants to assist with the extra travel expenses - and emotionally, through counselling for the whole family has helped immensely at this traumatic time.”
CLIC Sargent Fundraising Manager, Daisy Turner said: “Wig Wednesday was a great opportunity for schools, businesses, universities and communities to raise money and support children and young people with cancer.
"We can’t wait for next year’s event and hope to get even more local businesses involved.”
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